Antiphospholipid Syndrome (ASP) An Update - Special Reference To Recurrent Spontaneous Pregnancy Loss (RSPL)
نویسنده
چکیده
APS is an auto immune disease in which auto antibodies are detected against cell membrane phospholipids and is clinically characterised mainly by thrombocytopenia, thrombosis, neurologic and dermatologic manifestation and recurrent fetal loss. More recently it is found that these antibodies react with specific plasma proteins associated with phospholipids (e.g. β2 glycoprotein1 β2gp1) rather than against the anionic phospholipids directly.
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Antiphospholipid syndrome is an autoimmune condition characterized by recurrent vascular thrombosis, pregnancy loss and thrombocytopenia associated with moderate to high levels of antiphospholipid antibodies. Most of clinical features are results of thrombotic phenomena. The pathophysiologic basis ot this syndrome is still unknown. the diagnosis of this syndrome is made by combination of clinic...
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